Apocrine nevus is a rare benign hamartomatous proliferation characterized by an overgrowth of apocrine glands that displace normal dermal structures.

Apocrine nevi occur equally in both sexes, and there is no racial / ethnic predilection. Apocrine nevi can be congenital, develop around puberty, or appear in adulthood.

Typically, apocrine nevi present as fleshy, dome-shaped nodules. However, lesions can be aggregated papules, plaques, or masses. They may be unilateral or bilateral. They tend to enlarge over months to years.

Apocrine nevi have been reported to occur in association with syringocystadenoma papilliferum, apocrine carcinoma, and extramammary Paget disease. There are also rare reports of apocrine nevi occurring in individuals with neurofibromatosis, focal dermal hypoplasia, and seizure disorders. However, these relationships may be coincidental.