Dementia with Lewy bodies
Synopsis

Core clinical features include dementia, parkinsonism (bradykinesia, rigidity, tremor), fluctuating levels of alertness and cognition, visual hallucinations, and rapid eye movement (REM) sleep behavior disorder (dream enactment).
Additional features include frequent falls, orthostatic hypotension, constipation, urinary incontinence, neuroleptic sensitivity, myoclonus, depression, anxiety, apathy, systematized delusions, hypersomnia, and hyposmia.
Lack of response to levodopa is common; sustained dramatic positive response to levodopa should bring the diagnosis into question. Prognosis is poor, and most patients are significantly disabled within 5 years of diagnosis and die within 10 years of diagnosis.
Patients with this disorder may have an increased risk of various general medical conditions.
Codes
G31.83 – Dementia with Lewy bodies
SNOMEDCT:
80098002 – Diffuse Lewy body disease
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Last Updated:09/17/2020