The subcutaneous administration of heparin can induce a hypercoagulable state, resulting in intravascular thrombosis, infarction, and resultant skin necrosis. This usually occurs in diabetic women on high dose antibiotics, but unlike Coumadin necrosis (warfarin necrosis), heparin necrosis happens in men with relative frequency. Lethal thromboembolism has been reported. Hypersensitivity reactions to heparin can occur that are unrelated to the skin necrosis.